KCND1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)KRRAIRLANSTAS, corresponding to amino acid residues 538-550 of human Kv4.1. Intracellular, C-terminal domain.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel subfamily D member 1
Database Link	NP_004970 Entrez Gene 16506 MouseEntrez Gene 116695 RatEntrez Gene 3750 Human UniProt ID Q9NSA2
Background	Kv4.1 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: Kv4.2 and Kv4.3. Kv4.1 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of Kv4.1 and Kv4.2. The Kv4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of Kv4.1 and Kv4.2 subunits. The biophysical properties of the Kv4.1 subunit can be modified by its association with auxiliary b subunits such as KChIP1 that increase Kv4.1 current densities and accelerates both the inactivation and the recovery time. Kv4.1 is highly expressed in brain but is also expressed in peripheral tissues such as colon, heart and lung. The pharmacology of Kv4.1 has been less well studied than that of the other Kv4 members. Kv4.1 is sensitive to the classical K+ channel blockers, 4-aminopyridine and tetraethylammonium. Recently HmTx1 a peptide blocker derived from the venom of the African tarantula Heteroscodra maculata has been shown to be a potent inhibitor of Kv4.1.
Synonyms	KV4.1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.