CTIP2 (BCL11B) Rat Monoclonal Antibody [Clone ID: 25B6]

Specifications

Product Data
Clone Name	25B6
Applications	IF, WB
Recommend Dilution	WB, IF, CHIP, IHC
Reactivity	Human, Mouse, Zebrafish
Host	Rat
Clonality	Monoclonal
Immunogen	Human Bcl11b
Formulation	This antibody is provided in Hepes-buffered solution, pH 7.5, 0.02% NaN3.
Purification	Protein G affinity purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	96 kD
Gene Name	B-cell CLL/lymphoma 11B
Database Link	NP_612808 Entrez Gene 58208 MouseEntrez Gene 64919 Human UniProt ID Q9C0K0
Background	The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
Synonyms	ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; RIT1; ZNF856B
Reference Data
Protein Families	Druggable Genome

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