STAT2 Rabbit Polyclonal Antibody [Clone ID: Poly6245]

Specifications

Product Data
Clone Name	Poly6245
Applications	WB
Recommend Dilution	WB, IP
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide mapping to the carboxy terminus of human STAT2
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% gelatin.
Purification	The antibody was purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	113 kD
Gene Name	signal transducer and activator of transcription 2
Database Link	NP_005410 Entrez Gene 6773 Human UniProt ID P52630
Background	STAT2, a 113 kD member of the STAT (signal transducer and activators of transcription) protein family, is phosphorylated in response to interferon alpha receptor signaling by Janus kinase I. Phosphorylation of STAT 2 induces nuclear translocation to activate transcription. STAT2 is highly expressed in the skin and thymus. STAT 2 forms complex with STAT1 and p48 to activate transcription and does not bind DNA directly. STAT 3 interacts with interferon regulatory factor 9, interferon alpha receptor, STAT 1, p48, and CREB binding protein. The Poly6245 antibody recognizes the C-terminal region of human STAT2 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.
Synonyms	IMD44; ISGF-3; P113; STAT113
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Chemokine signaling pathway, Jak-STAT signaling pathway

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