XBP1 Mouse Monoclonal Antibody [Clone ID: 143F]

Specifications

Product Data
Clone Name	143F
Applications	WB
Recommend Dilution	WB, IHC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	XBP-1s recombination protein
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	X-box binding protein 1
Database Link	NP_005071 Entrez Gene 7494 Human UniProt ID P17861
Background	XBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its binding ability to X-box, a conserved transcriptional element in the promoter of human HLA DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 upregulates as part of the ER stress response, also known as the unfolded protein response. Unspliced XBP-1 is 261 amino acids and migrates on the SDS-PAGE around 33 kD; spliced XBP-1, recognized by clone 143F, is 371 amino acids and migrates around 55 kD.
Synonyms	TREB-5; TREB5; XBP-1; XBP2
Reference Data
Protein Families	Transcription Factors

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