p63 (TP63) Rabbit Polyclonal Antibody [Clone ID: Poly6190]

Specifications

Product Data
Clone Name	Poly6190
Applications	IF, WB
Recommend Dilution	WB, IF, IHC
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Modified peptide
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Purification	The antibody was purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kD, 45 kD
Gene Name	tumor protein p63
Database Link	NP_003713 Entrez Gene 8626 Human UniProt ID Q9H3D4
Background	p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.
Synonyms	AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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