H3FT (HIST3H3) Rat Monoclonal Antibody [Clone ID: HTA28]

Specifications

Product Data
Clone Name	HTA28
Applications	IF, WB
Recommend Dilution	WB, IP, ICFC, IF, CyTOF
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	Synthetic peptide conjugated to KLH, corresponding to amino acids 23-35 of Human Histone H3.
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone cluster 3, H3
Database Link	NP_003484 Entrez Gene 8290 Human UniProt ID Q16695
Background	H3 is a core component of the nucleosome that serves to wrap and compact DNA into chromatin.Histones therefore, limit the accessibility of DNA, providing mechanisms for transcription regulation, DNA repair and replication and chromosomal stability.During mitosis, H3 is phosphorylated at serine 28.This phosphorylation coincides with chromosome condensation initiated at prophase and disappears at late anaphase H3 has been demonstrated to be phosphorylated by the action of MLTK-α (mixed linage kinase-like mitogen activated protein triple kinase α) in response to ultraviolet B light and epidermal growth factor, as well as Aurora-B during mitosis.
Synonyms	g; H3; H3.4; H3FT; H3t
Reference Data
Protein Pathways	Systemic lupus erythematosus

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