TSH beta (TSHB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	thyroid stimulating hormone beta
Database Link	NP_000540 Entrez Gene 7252 Human UniProt ID P01222
Synonyms	TSH-B; TSH-BETA
Note	Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulate the endocrine function of the thyroid gland. TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit, which are non-covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones: Follicle stimulating hormone and luteinizing hormone and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.Anti-TSH reacts with TSH-producing cells (thyrotrophs), and is a useful marker in classification of pituitary tumors and the differential identification of primary and metastatic tumors in the pituitary gland.
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

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