TPSAB1 Mouse Monoclonal Antibody [Clone ID: G3]

Specifications

Product Data
Clone Name	G3
Applications	IHC
Recommend Dilution	IHC: 1:200 - 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tryptase alpha/beta 1
Database Link	NP_003285 Entrez Gene 7177 Human UniProt ID Q15661
Synonyms	TPS1; TPS2; TPSB1
Note	Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are stored in mast cell secretory granules and basophils. These enzymes are released into the extracellular environment, and are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There are two separate genes: alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.Anti-tryptase is a good marker for mast cells, basophils, and their derivatives. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in the differential diagnosis of reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.