Mucin 5AC (MUC5AC) Mouse Monoclonal Antibody [Clone ID: MRQ-19]

Specifications

Product Data
Clone Name	MRQ-19
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mucin 5AC, oligomeric mucus/gel-forming
Database Link	NP_059981 Entrez Gene 4586 Human UniProt ID P98088
Synonyms	gastric; gastric mucin; gel-forming; MUC5; mucin 5; mucin 5AC; oligomeric mucus; subtypes A and C; tracheobronchial; tracheobronchial mucin
Note	Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium. The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma. Pinto-de-Sousa et al. have shown, in a comprehensive study of gastric carcinomas evaluated for expression of several mucins (MUC1, MUC2, MUC5AC and MUC6), that: (1) mucin expression is associated with tumor type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behavior of the tumors; and (2) mucin expression is associated with tumor location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumor differentiation according to tumor location. The following generalities apply to the patterns of MUC5AC expression: Preferentially expressed in the normal stomach and respiratory tract; esophageal carcinomas – 67%, gastric carcinomas – 58%, colonic carcinomas – 6%-25%, pancreatic ductal carcinomas – 73%, cholangiocarcinomas – 45%, endocervical adenocarcinomas – 70%, endometrial adenocarcinomas – 22%, and lung adenocarcinomas – 14%.
Reference Data
Protein Families	Druggable Genome

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