CD8A Mouse Monoclonal Antibody [Clone ID: C8/144B]
CNY 11,325.00
货期*
5周
规格
经常一起买 (3)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | C8/144B |
Applications | IHC |
Recommend Dilution | IHC: 1:25 - 1:100 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Formulation | This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | CD8a molecule |
Database Link | |
Synonyms | CD8; Leu2; MAL; p32 |
Note | The CD8 (cluster of differentiation 8) antigen is a cell surface glycoprotein found on most cytotoxic T-lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). TCR is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T-helper and cytotoxic T-cells that can be distinguished by their expression of CD4 and CD8 respectively. CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. The CD8 co-receptor is predominantly expressed on the surface of suppressor and cytotoxic T-cells at a low level by NK cells, large granular lymphocyte leukemia, and some T-ALL/T-LBL.For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4, is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas (CD4+/CD8-). Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. |
Reference Data | |
Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
Protein Pathways | Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway |
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