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RRM2 Rabbit Polyclonal Antibody
CAT＃: TA327571S
RRM2 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
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Specifications
| Product Data | |
| Applications | ICC/IF, IHC, IP, WB |
| Recommend Dilution | WB 1:500 - 1:2000;IF 1:10 - 1:100 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human RRM2 |
| Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 45 kDa |
| Gene Name | ribonucleotide reductase regulatory subunit M2 |
| Database Link | |
| Background | Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5-diphosphates into 2-deoxyribonucleotides, a rate-limiting step in the production of 2-deoxyribonucleoside 5-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit. |
| Synonyms | R2; RR2; RR2M |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism |
Documents
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Resources
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