DUSP1 Rabbit Polyclonal Antibody

CAT#: TA327446S

Rabbit anti-DUSP1 Polyclonal Antibody

Size: 20 ul 100 ul



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CN¥ 800.00


货期*
2周

规格
    • 20 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500-1:2000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide of human DUSP1
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name dual specificity phosphatase 1
Background The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Synonyms CL100; HVH1; MKP-1; MKP1; PTPN10
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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