Integrin beta 4 binding protein (EIF6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50- 1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human EIF6
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	eukaryotic translation initiation factor 6
Database Link	NP_852133 Entrez Gene 16418 MouseEntrez Gene 305506 RatEntrez Gene 3692 Human UniProt ID P56537
Background	Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus. In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes. eIF6 is also shown to associate with the RNA-induced silencing complex (RISC). Deletion of eIF6 abolishes the miRNA-mediated gene silencing. eIF6 may play its essential role in miRNA-mediated silencing by inhibiting translation initiation or ribosome recycling.
Synonyms	b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP; p27(BBP); p27BBP
Reference Data
Protein Families	Druggable Genome

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