CDC25C Rabbit Polyclonal Antibody

CAT#: TA327133

CDC25C Rabbit Polyclonal Antibody



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CNY 1,999.00

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货期*
2周

规格
    • 100 ul

Product images

经常一起买 (4)
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Recombinant protein of human cell division cycle 25 homolog C (S. pombe) (CDC25C), transcript variant 1, 100 µg
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution WB 1:500 - 1:2000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human CDC25C
Formulation PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name cell division cycle 25C
Background Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint. When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage.
Synonyms CDC25; PPP1R60
Reference Data
Protein Families Druggable Genome, Phosphatase, Stem cell - Pluripotency
Protein Pathways Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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