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RASSF1 Rabbit Polyclonal Antibody
CAT＃: TA326994S
Rabbit anti-RASSF1 Polyclonal Antibody
Size: 100 ul
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CN¥ 800.00
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Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB 1:500 - 1:2000 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human RASSF1 |
| Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | Ras association domain family member 1 |
| Database Link | |
| Background | This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Synonyms | 123F2; NORE2A; RASSF1A; RDA32; REH3P21 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Bladder cancer, Non-small cell lung cancer, Pathways in cancer |
Documents
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