RHOC Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human RHOC
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ras homolog family member C
Database Link	NP_786886 Entrez Gene 295342 RatEntrez Gene 389 Human UniProt ID P08134
Background	Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI) (1). RhoA, RhoB and RhoC are highly homologous, but appear to have divergent biological functions. Carboxy-terminal modifications and differences in subcellular localization allow these three proteins to respond to and act on distinct signaling molecules (2,3).1. DerMardirossian, C. and Bokoch, G.M. (2005) Trends Cell Biol 15, 356-63.2. Wennerberg, K. and Der, C.J. (2004) J Cell Sci 117, 1301-12.3. Wheeler, A.P. and Ridley, A.J. (2004) Exp Cell Res 301, 43-9.
Synonyms	ARH9; ARHC; H9; RHOH9
Reference Data
Protein Families	Druggable Genome

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