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IL2 Rabbit Polyclonal Antibody
CAT＃: TA326824S
IL2 Rabbit Polyclonal Antibody
Size: 100 ul
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CN¥ 800.00
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Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB 1:500 - 1:2000 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human IL2 |
| Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 18 kDa |
| Gene Name | interleukin 2 |
| Database Link | |
| Background | IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of Treg cells. Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Ra, IL-2Rβ and the common gamma chain, ?c . IL-2 Ra binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and ?c subunits. IL-2Rβ is also used by IL-15 . The common ?c is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 . Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways . |
| Synonyms | IL-2; lymphokine; TCGF |
| Reference Data | |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus |
Documents
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Resources
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