NGF Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide of human NGF
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27 kDa
Gene Name	nerve growth factor
Database Link	NP_002497 Entrez Gene 18049 Mouse UniProt ID P01138
Background	Nerve growth factor (NGF) is a small, secreted protein and member of the neurotrophin family of growth factors that promote neuronal cell survival and differentiation. Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to a low affinity p75 (NTR) receptors, which belong to the death receptor family. Although NGF has been classically described as favoring neuron survival and differentiation, nerve growth factor can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death in a variety of neurodegenerative conditions, including Alzheimer disease. Besides its neurotrophic actions, NGF has an effect on non-neuronal cells and may help mediate inflammation, angiogenesis, and stimulate breast cancer cell growth. NGF signaling is looking increasingly promising as potential drug targets for diseases.
Synonyms	Beta-NGF; HSAN5; NGFB
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Apoptosis, MAPK signaling pathway, Neurotrophin signaling pathway

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