GDF15 Rabbit Polyclonal Antibody
CAT#: TA326764
Rabbit anti-GDF15 Polyclonal Antibody
Need it in bulk or conjugated?
Get a free quote
热销推荐
CNY 1,999.00
CNY 2,700.00
货期*
2周
规格
经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | ICC/IF, IHC, IP, WB |
Recommend Dilution | WB 1:500 - 1:2000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human GDF15 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | growth differentiation factor 15 |
Database Link | |
Background | Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15, PTGF-β, PLAB, PDF, and NAG-1, is a divergent member of the transforming growth factor-β (TGF-β) superfamily. Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid. It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity. During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer. |
Synonyms | GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...