Perforin (PRF1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IF, IHC, WB
Recommend Dilution	WB 1:500 - 1:1000 IHC-P 1:50 - 1:200 IF/ICC 1:50 - 1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human PRF1
Formulation	PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	perforin 1
Database Link	NP_005032 Entrez Gene 18646 MouseEntrez Gene 50669 RatEntrez Gene 5551 Human UniProt ID P14222
Background	Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells. Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates.Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, such as granzymes, into target cells. Perforin is primarily expressed in cytotoxic T lymphocytes and NK cells.
Synonyms	FLH2; HPLH2; P1; PFN1; PFP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Allograft rejection, Autoimmune thyroid disease, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Viral myocarditis

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