MAP1LC3A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	MAP1LC3A antibody was raised against a 10 amino acid peptide near the amino terminus of human MAP1LC3A.
Formulation	MAP1LC3A antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	MAP1LC3A antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 147 kDa; Observed: 21 kDa
Gene Name	microtubule associated protein 1 light chain 3 alpha
Database Link	NP_852610 Entrez Gene 84557 Human UniProt ID Q9H492
Background	Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1). MAP1LC3A belongs to the MAP1 LC3 family of proteins that form mature complexes with MAP1A and MAP1B which are thought to be important in the formation and development of axons and dendrites (2). MAP1LC3A is one of three isoforms of MAP1LC3, the mammalian homolog of yeast ATG8, an essential autophagy protein. These isoforms exhibit distinct expression patterns and MAP1LC3A, like MAP1LC3A but not MAP1LC3B, is post-translationally modified, suggesting the three isoforms may have different physiological functions (3).
Synonyms	ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3
Reference Data

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