IL36 alpha (IL36A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	IL-36A antibody was raised against an 11 amino acid peptide near the carboxy terminus of human IL-36A.
Formulation	IL-36A antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IL-36A antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 17 kDa; Observed: 16 kDa
Gene Name	interleukin 36, alpha
Database Link	NP_055255 Entrez Gene 27179 Human UniProt ID Q9UHA7
Background	IL-36A is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36A is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2). Like the related proteins IL-36B and IL-36G, IL-36A requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3). The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (4).
Synonyms	FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL1(EPSILON); IL1F6
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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