FHIT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	FHIT antibody was raised against an 18 amino acid peptide near the carboxy terminus of human FHIT.
Formulation	FHIT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	FHIT Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 16 kDa; Observed: 15 kDa
Gene Name	fragile histidine triad
Database Link	NP_002003 Entrez Gene 14198 MouseEntrez Gene 2272 Human UniProt ID P49789
Background	FHIT is member of the histidine triad gene family and is a diadenosine involved in purine metabolism (1). FHIT is also thought to be a tumor suppressor gene and is involved in multiple apoptotic pathways (1,2). The FHIT gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene (3). Aberrant transcripts from this gene have been found in multiple carcinomas (4).
Synonyms	AP3Aase; FRA3B
Reference Data
Protein Pathways	Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

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