SCUBE3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3.
Formulation	SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SCUBE3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 109 kDa
Gene Name	signal peptide, CUB domain and EGF like domain containing 3
Database Link	NP_689966 Entrez Gene 222663 Human UniProt ID Q8IX30
Background	SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.
Synonyms	CEGF3
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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