Slc12a3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	AA74-95 (rat), 76-97 (hum)
Formulation	PBS, 50% glycerol and 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 12 member 3
Database Link	NP_062218 Entrez Gene 6559 HumanEntrez Gene 20497 MouseEntrez Gene 54300 Rat UniProt ID P55018
Background	NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis . Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1. In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC . Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension . Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat .
Synonyms	FLJ96318; NCCT; TSC
Note	Detects ~160kDa.
Reference Data

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