Slc12a1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	AA109 to 129 of the rat sequence
Formulation	PBS, 50% glycerol and 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 12 member 1
Database Link	NP_062007 Entrez Gene 6557 HumanEntrez Gene 20495 MouseEntrez Gene 25065 Rat
Background	NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell . Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide .
Synonyms	BSC1; MGC48843; NKCC2
Note	Detects ~160kDa.
Reference Data

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