Nalcn Mouse Monoclonal Antibody [Clone ID: S187-7]

Specifications

Product Data
Clone Name	S187-7
Recommend Dilution	WB: 1ug/ml
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids1659-1738 (cytoplasmic Cterminus) of rat NALCN
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium leak channel, non-selective
Database Link	NP_705894 Entrez Gene 338370 MouseEntrez Gene 266760 Rat UniProt ID Q6Q760
Background	NALCN (sodium leak channel non-selective protein), also known as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system.Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable tosodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductancein neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
Synonyms	bA430M15.1; CanIon; FLJ23913; FLJ44659; FLJ44764; MGC74524; VGCNL1
Note	Detects ~200kDa.
Reference Data

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