Aqp4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB 1:1000-4000, IF: 1:400
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal peptide
Formulation	PBS pH7.4, 50% glycerol and 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	aquaporin 4
Database Link	NP_036957 Entrez Gene 361 HumanEntrez Gene 11829 MouseEntrez Gene 25293 Rat UniProt ID P47863
Background	Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins .Aquaporin 4 is constitutively expressed in the basolateral cell membrane of princinpal collecting duct cells in the kidney and provide a pathway for water to exit these cells . It is also expressed in astrocytes and is upregulated by direct insult to the CNS . Aquaporin 4 has been propsed as the primary autoimmune target in neuromyelitis optica .
Synonyms	AQP-4; aquaporin-4; HMIWC2; MGC22454; MIWC; WCH4
Note	Detects ~35kDa. May detect larger glycosylated bands ~50kDa.
Reference Data

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