Dicer (DICER1) Mouse Monoclonal Antibody [Clone ID: S167-7]

Specifications

Product Data
Clone Name	S167-7
Recommend Dilution	WB: 1ug/ml
Reactivity	Mouse, Rat, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	dicer 1, ribonuclease III
Database Link	NP_001258211 Entrez Gene 192119 MouseEntrez Gene 299284 RatEntrez Gene 23405 Human UniProt ID Q9UPY3
Background	Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs) . After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha , pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs . The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA .
Synonyms	DCR1; Dicer; Dicer1e; HERNA; K12H4.8-LIKE; MNG1; RMSE2
Note	Detects ~215kDa.
Reference Data
Protein Families	Druggable Genome

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