DNMT1 Mouse Monoclonal Antibody [Clone ID: 60B1220.1]

CAT#: TA326439

Mouse monoclonal DNMT1 Antibody



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CNY 5,830.00


货期*
4周

规格
    • 100 ug

Cited in 4 publications.

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Specifications

Product Data
Clone Name 60B1220.1
Applications IHC, WB
Recommend Dilution WB: 2-4ug/ml, IHC: 1-2ug/ml
Reactivity Human, Mouse, Zebrafish
Host Mouse
Clonality Monoclonal
Immunogen Raised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1 (Gene
Formulation PBS, 0.05% BSA, 0.05% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name DNA (cytosine-5-)-methyltransferase 1
Background Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells .
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Note It will cross-react with mouse DNMT1.
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Cysteine and methionine metabolism, Metabolic pathways
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (4)

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