alpha A Crystallin (CRYAA) Mouse Monoclonal Antibody [Clone ID: 1H3.B8]

Specifications

Product Data
Clone Name	1H3.B8
Applications	WB
Recommend Dilution	WB: 1:2000
Reactivity	Human, Mouse, Cow, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Native Alpha Crystallin
Formulation	PBS pH7.2, in 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	crystallin alpha A
Database Link	NP_000385 Entrez Gene 12954 MouseEntrez Gene 24273 RatEntrez Gene 1409 Human UniProt ID P02489
Background	The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27 . Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its phosphorylated state and may serve a structural control function and play a role in protein maintenance . In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases .
Synonyms	CRYA1; CTRCT9; HSPB4
Note	Detects a-crystallin at ~20kDa. Does not cross-react with aB-crystallin, βL-crystallin, ?H- crystallin, ?-crystallin, Hsp25, Hsp27 or Hsp47 proteins.
Reference Data

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