PSD95 (DLG4) Mouse Monoclonal Antibody [Clone ID: S28-43]

CAT#: TA326433

Mouse monoclonal PSD95 Antibody



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CNY 5,830.00


货期*
4周

规格
    • 100 ug

Product images

经常一起买 (4)
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Recombinant protein of human discs, large homolog 4 (Drosophila) (DLG4), transcript variant 1, 100 µg
    • 100 ug

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Specifications

Product Data
Clone Name S28-43
Applications IF, IHC
Recommend Dilution WB: 1:1000
Reactivity Mouse, Rat, Human
Host Mouse
Clonality Monoclonal
Immunogen Fusion protein amino acids 77-200 of human PSD95/SAP90
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name discs large MAGUK scaffold protein 4
Background Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Synonyms PSD95; SAP-90; SAP90
Note Detects ~95-110kDa.
Reference Data
Protein Families Druggable Genome
Protein Pathways Huntington's disease
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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