Amigo1 Mouse Monoclonal Antibody [Clone ID: S86-36]

Specifications

Product Data
Clone Name	S86-36
Recommend Dilution	WB: 1:1000
Reactivity	Mouse, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 395-493 (cytoplasmic C-terminus) of mouse AMIGO-1.
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adhesion molecule with Ig like domain 1
Database Link	Entrez Gene 229715 Mouse UniProt ID Q80ZD8
Background	The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. They can form complexes with each other, but can also self-bind.AMIGO1, also designated Alivin2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin3) plays a role in hemophilic and/or heterophilic cell-cell interaction and signal transduction.
Synonyms	ALI2; AMIGO; AMIGO-1
Note	Detects 60-80kDa depending on maturity/glycosylation
Reference Data

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