Superoxide Dismutase 1 (SOD1) Rabbit Polyclonal Antibody [Clone ID: N/A]

Specifications

Product Data
Clone Name	N/A
Applications	IF, WB
Recommend Dilution	0.2ug/ml was sufficient for detection of Cu/Zn SOD in 20ug of HeLa cell lysate
Reactivity	Human, Rat, Mouse, Bovine, Monkey, Dog, Hamster, Rabbit, Pig, Sheep, Xenopus, Coral
Host	Rabbit
Clonality	Polyclonal
Immunogen	Human Cu/Zn SOD
Formulation	PBS pH7.0, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Affinity (antigen) Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	superoxide dismutase 1, soluble
Database Link	NP_000445 Entrez Gene 20655 MouseEntrez Gene 24786 RatEntrez Gene 403559 DogEntrez Gene 574096 MonkeyEntrez Gene 6647 Human UniProt ID P00441
Background	Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2¯to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space. SOD3 can also be distinguished by its heparin-binding capacity .
Synonyms	ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD
Note	Detects a ~23kDa (human) and 19kDa (other species) proteins corresponding to the molecular mass of Cu/Zn superoxide dismutase (SOD) on SDS PAGE immunoblots.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases

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