EIF4EBP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000; IHC: 1:50-1:200
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	The antiserum was produced against A synthesized peptide derived from human 4E-BP1 around the phosphorylation site of Threonine 45
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	18 kDa
Gene Name	eukaryotic translation initiation factor 4E binding protein 1
Database Link	NP_004086 Entrez Gene 13685 MouseEntrez Gene 116636 RatEntrez Gene 1978 Human UniProt ID Q13541
Background	4E-BP1 binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation.
Synonyms	4E-BP1; 4EBP1; BP-1; PHAS-I
Reference Data
Protein Pathways	Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway

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