IL15RA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse spleen tissue, Mouse fat tissue, Mouse lung tissue, Human placenta tissue, Rat liver tissue lysates IHC: 50-200 Positive control: Human tonsil Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 250-264 amino acids of Human interleukin 15 receptor, alpha
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kDa
Gene Name	interleukin 15 receptor subunit alpha
Database Link	NP_001230468 Entrez Gene 16169 MouseEntrez Gene 690369 RatEntrez Gene 3601 Human UniProt ID Q13261
Background	This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits; IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha; an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA; IL15RA is capable of binding IL15 with high affinity independent of other subunits; which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
Synonyms	CD215
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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