Kallikrein 7 (KLK7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 30-253 amino acids of human kallikrein-related peptidase 7
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	kallikrein related peptidase 7
Database Link	NP_644806 Entrez Gene 5650 Human UniProt ID P49862
Background	This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation; the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis; and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene; which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
Synonyms	hK7; PRSS6; SCCE
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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