MEK5 (MAP2K5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 172-409 amino acids of human mitogen-activated protein kinase kinase 5
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mitogen-activated protein kinase kinase 5
Database Link	NP_660145 Entrez Gene 23938 MouseEntrez Gene 29568 RatEntrez Gene 5607 Human UniProt ID Q13163
Background	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3; as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Synonyms	dual specificity mitogen-activated protein kinase kinase 5; ERK kinase 5; HsT17454; MAPK; MAP kinase kinase MEK5b; MAPKK5; MEK5; mitogen-activated protein kinase kinase 5; PRKMK5
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Gap junction, MAPK signaling pathway, Neurotrophin signaling pathway

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