STEAP4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: HepG2 cell lysate IHC: 40-200 Positive control: Human liver cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 441-456 amino acids of human STEAP family member 4
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	STEAP4 metalloreductase
Database Link	NP_078912 Entrez Gene 117167 MouseEntrez Gene 79689 Human UniProt ID Q687X5
Background	The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family; and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+); using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism; and may contribute to the normal biology of the prostate cell; as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	STAMP2; TIARP; TNFAIP9
Reference Data
Protein Families	Druggable Genome, Transmembrane

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