gamma Actin (ACTG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Human liver cancer tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 4-379 amino acids of human actin, gamma 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	actin gamma 1
Database Link	NP_001186883 Entrez Gene 11465 MouseEntrez Gene 287876 RatEntrez Gene 71 Human UniProt ID P63261
Background	Actins are highly conserved proteins that are involved in various types of cell motility; and maintenance of the cytoskeleton. In vertebrates; three main groups of actin isoforms; alpha; beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton; and as mediators of internal cell motility. Actin; gamma 1; encoded by this gene; is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26; a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.
Synonyms	ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176
Reference Data
Protein Pathways	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Tight junction, Vibrio cholerae infection, Viral myocarditis

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