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Gremlin 1 (GREM1) Rabbit Polyclonal Antibody
CAT＃: TA324077S
Anti-GREM1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Mouse testis tissue |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 25-184 amino acids of human gremlin 1 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 21 kDa |
| Gene Name | gremlin 1, DAN family BMP antagonist |
| Database Link | |
| Background | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs; BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists; to which this gene belongs; is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP; this gene may play a role in regulating organogenesis; body patterning; and tissue differentiation. In mouse; this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2 |
| Reference Data | |
| Protein Families | ES Cell Differentiation/IPS, Secreted Protein |
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