Gremlin 1 (GREM1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse testis tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 25-184 amino acids of human gremlin 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	21 kDa
Gene Name	gremlin 1, DAN family BMP antagonist
Database Link	NP_001178251 Entrez Gene 23892 MouseEntrez Gene 50566 RatEntrez Gene 26585 Human UniProt ID O60565
Background	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs; BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists; to which this gene belongs; is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP; this gene may play a role in regulating organogenesis; body patterning; and tissue differentiation. In mouse; this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
Reference Data
Protein Families	ES Cell Differentiation/IPS, Secreted Protein

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