FHIT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse brain and human fetal kidney tissue IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	17 kDa
Gene Name	fragile histidine triad
Database Link	NP_001159715 Entrez Gene 14198 MouseEntrez Gene 60398 RatEntrez Gene 2272 Human UniProt ID P49789
Background	This gene; a member of the histidine triad gene family; encodes a diadenosine 5';5'''-P1;P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3; where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact; aberrant transcripts from this gene have been found in about half of all esophageal; stomach; and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
Synonyms	AP3Aase; FRA3B
Reference Data
Protein Pathways	Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

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