LTA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 36-205 amino acids of human lymphotoxin alpha (TNF superfamily, member 1)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lymphotoxin alpha
Database Link	NP_000586 Entrez Gene 4049 Human UniProt ID P01374
Background	The encoded protein; a member of the tumor necrosis factor family; is a cytokine produced by lymphocytes. The protein is highly inducible; secreted; and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory; immunostimulatory; and antiviral responses; is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4; myocardial infarction; non-Hodgkin's lymphoma; and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
Synonyms	LT; TNFB; TNFSF1
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cytokine-cytokine receptor interaction, Type I diabetes mellitus

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