GAS 6 (GAS6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 10-50 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 690-705 amino acids of Human growth arrest-specific 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	growth arrest specific 6
Database Link	NP_000811 Entrez Gene 2621 Human UniProt ID Q14393
Background	This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation; and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Ligand for tyrosine-protein kinase receptors AXL; TYRO3 and MER whose signaling is implicated in cell growth and survival; cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses.
Synonyms	AXLLG; AXSF
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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