NMDAR1 (GRIN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 35-49 amino acids of human glutamate receptor, ionotropic, N-methyl D-aspartate 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	glutamate ionotropic receptor NMDA type subunit 1
Database Link	NP_000823 Entrez Gene 14810 MouseEntrez Gene 24408 RatEntrez Gene 2902 Human UniProt ID Q05586
Background	The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors; members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses; which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms; possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Synonyms	GluN1; MRD8; NMD-R1; NMDA1; NMDAR1; NR1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
Protein Pathways	Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction

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