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Natriuretic Peptide Receptor A (NPR1) Rabbit Polyclonal Antibody
CAT＃: TA323535S
Anti-NPR1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm, Nucleus, Cell membrane |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 525-541 amino acids of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | natriuretic peptide receptor 1 |
| Database Link | |
| Background | Guanylyl cyclases; catalyzing the production of cGMP from GTP; are classified as soluble and membrane forms . The membrane guanylyl cyclases; often termed guanylyl cyclases A through F; form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain; a single membrane-spanning domain; and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962); which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295); respectively). |
| Synonyms | ANPa; ANPRA; GUC2A; GUCY2A; NPRA |
| Reference Data | |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Purine metabolism, Vascular smooth muscle contraction |
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