PRMT5 Rabbit Polyclonal Antibody
CAT#: TA323372S
Anti-PRMT5 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 1,280.00
CNY 300.00
CNY 1,430.00
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CNY 3,080.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 200-1000 WB positive control: K562, hela and 293T cells IHC: 15-50 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide peptide corresponding to a region derived from 622-637 amino acids of human protein arginine methyltransferase 5 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 71 kDa |
Gene Name | protein arginine methyltransferase 5 |
Database Link | |
Background | Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77; CLNS1A; Janus kinase 2; SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. |
Synonyms | HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs |
Reference Data | |
Protein Families | Stem cell - Pluripotency |
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