PAR6 (PARD6A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:25-100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 334-346 amino acids of human par-6 partitioning defective 6 homolog alpha (C. elegans)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	37 kDa
Gene Name	par-6 family cell polarity regulator alpha
Database Link	NP_001032358 Entrez Gene 56513 MouseEntrez Gene 307799 RatEntrez Gene 50855 Human UniProt ID Q9NPB6
Background	This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants; encoding different isoforms; have been characterized.
Synonyms	PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40; TIP-40
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Endocytosis, Tight junction

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