CTBP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: PC3 cells IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 300 amino acids of human C-terminal binding protein 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	106 kDa
Gene Name	C-terminal binding protein 2
Database Link	NP_001077383 Entrez Gene 13017 MouseEntrez Gene 81717 RatEntrez Gene 1488 Human UniProt ID P56545
Background	This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor; while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however; it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
Synonyms	C-terminal binding protein 2; OTTHUMP00000020699; OTTHUMP00000020701; ribeye
Reference Data
Protein Families	Stem cell - Pluripotency, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways	Chronic myeloid leukemia, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

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